Targeting Clostridioides difficile Infection-Induced Inflammation to Improve Treatment Outcome

Clostridioides difficile infection (CDI) is a worldwide concern. The increase in cases numbers and disease severity mortality combined with the scarcity of effective antibiotics warrant intensive research for alternative strategies to combat this disease. Although CDI inflammatory nature, antiinflammatory agents are not recommended management symptoms. Further, some drugs considered predisposing factors severe poor prognosis. On other hand, several studies have demonstrated benefit curbing inflammation both humans experimental animals. Since multifactorial that depends on host immunity, gut microbiota bacterial virulence, thorough investigation required assess value using treatment infection. current article highlights conflicting evidence during calls in-depth evaluate their use controlling CDI.